Biolide
For Effective Weight Management
Biolide is a weight loss medicine that contains the active substance Liraglutide. It is similar to a natural occurring hormone called glucagon-like peptide-1 (GLP-1) that is released from the intestine after a meal. Biolide works by acting on receptors in the brain that controls one’s appetite, leading one to feel fuller. This can, in turn, stave off hunger and help control weight gain. Biolide is used to aid weight loss among adults and adolescents aged 12 years and above. When combined with a healthy diet and regular exercise, Biolide aids in sustainable weight loss for individuals with chronic obesity or weight-related health conditions.
Indications for Use
Adults (18+ years)
- With a Body Mass Index (BMI) of 30 kg/m² or greater (obese)
- Or a BMI of 27 kg/m² to less than 30 kg/m² (overweight) with weight-related health conditions (such as high blood pressure, diabetes, abnormal levels of fats in the blood, and breathing problems during sleep).
Adolescents (12+ years)
- Diagnosed with obesity
- With a body weight above 60 kg
How Biolide Works
Biolide contains Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue with 97% homology to human GLP-1.
The mechanism of action includes:
GLP-1 Receptor Activation
Liraglutide binds to and activates the GLP-1 receptor, helping control hunger by increasing feelings of fullness and reducing food intake.
Reduction of Fat Mass
Liraglutide promotes fat loss, especially in visceral areas, while minimally affecting subcutaneous fat.
Insulin and Glucagon Regulation
Stimulates insulin secretion and reduces glucagon levels in a glucose-dependent manner, aiding in glycaemic control.
Studies have shown that Liraglutide helps improve and sustain beta-cell function, aiding long-term weight management and glucose control.
Recommended Treatment Guidelines
- Adult Patients: Should continue using Biolide only if there is at least a 5% reduction in initial body weight after 12 weeks on the 3.0 mg/day dose.
- Adolescent Patients: Recommended for continued use only if there is a 4% reduction in BMI after 12 weeks on the 3.0 mg/day or maximum tolerated dose.
A healthcare provider will develop a tailored diet and exercise program at the start of the treatment, which should be maintained throughout the therapy with Biolide.
Potential Side Effects
Like all medications, Biolide may cause side effects in some patients. It is essential to consult with a healthcare provider if any side effects occur.
Serious Side Effects
(seek immediate medical help)
(seek immediate medical help)
- Severe allergic reactions (anaphylaxis) with symptoms like breathing difficulties, swelling of the face/throat, and a rapid heartbeat.
- Inflammation of the pancreas (pancreatitis) with symptoms such as severe and persistent pain in the abdomen, which might start from one's back, as well as nausea and vomiting, as it could be a sign of an inflamed pancreas (pancreatitis).
Less Common Side Effects
(may affect up to 1 in 100 people)
(may affect up to 1 in 100 people)
- Dehydration, delayed stomach emptying, inflamed gallbladder.
- Allergic reactions, including skin rash, faster pulse, and feeling generally unwell.
Common Side Effects
(may affect up to 1 in 10 people)
(may affect up to 1 in 10 people)
- Nausea, vomiting, diarrhea, constipation, headache
- Indigestion, stomach pain, heartburn, and bloating
- Dizziness, feeling tired, changes in taste, insomnia
- Gallstones, skin rash, or injection site reactions
- Low blood sugar (hypoglycaemia), especially if taking other diabetes medications
Rare Side Effects
(may affect up to 1 in 1000 people)
(may affect up to 1 in 1000 people)
Reduced kidney function or acute kidney failure
Reporting Side Effects
If you experience any side effects, consult your doctor, pharmacist, or nurse.
Additionally, side effects can be reported directly through the Yellow Card
Scheme at www.mhra.gov.uk/yellowcard or by downloading the MHRA Yellow Card
app from the Google Play or Apple App Store. Additionally, you can also report
adverse events at https://pharmacovigilancesmv.biocon.com/