Patient Resources
About Obesity
Obesity is a chronic and complex disease characterized by excessive accumulation of body fat, which can negatively impact one’s health. It is not simply a matter of appearance, but is linked to serious health conditions. Obesity significantly increases the risk of developing type 2 diabetes, heart disease, high blood pressure, and stroke. It can also have negative effects on bone health, reproductive function, and raise the risk of certain cancers, such as breast, colon, and liver cancer.
Beyond its physical health consequences, obesity can also impair the quality of life. It can lead to difficulties in performing everyday activities like walking or sleeping, and it may result in social and psychological challenges due to social stigma and decreased self-esteem.
Body Mass Index (BMI)
Weight Categories
BMI (Kg/m²)
below 18.5
18.5 to 24.9
25 to 29.9
30 to 39.9
40 or above
However, BMI scores have some limitations because it measures whether a person is carrying too much weight but not too much fat. For example, people who are very muscular, like professional sportspeople, can have a high BMI without much fat.
But for most people, BMI is a useful indication of whether they have a healthy weight. One can use the NHS BMI healthy weight calculator to calculate their BMI.
Risk factors
- Obesity is influenced by a combination of genetic, environmental, behavioral, and socioeconomic factors. This includes:
- Genetics and family history
- Poor diet
- Physical inactivity
- Hormonal factors
- Prediabetes, a condition where blood sugar levels are higher than normal but not yet high enough to be classified as diabetes
- While some risk factors (like genetics and age) are beyond one’s control, many can be modified through lifestyle changes, such as healthier eating, increased physical activity, and stress management.
Serious complications
- Living with obesity can also increase one’s risk of developing many potentially serious health conditions, including:
- Type 2 diabetes
- High blood pressure
- High cholesterol and atherosclerosis (where fatty deposits narrow one’s arteries), which can lead to coronary heart disease and stroke
- Asthma
- Metabolic syndrome, a combination of diabetes, high blood pressure and obesity
- Several types of cancer, including bowel cancer, breast cancer and womb cancer
- Gastro-oesophageal reflux disease (GORD), where stomach acid leaks out of the stomach and into the gullet
- Gallstones
- Reduced fertility
- Osteoarthritis, a condition involving pain and stiffness in one’s joints
- Sleep apnoea, a condition that causes interrupted breathing during sleep, which can lead to daytime sleepiness
- Liver disease and kidney disease
- Pregnancy complications, such as gestational diabetes or pre-eclampsia, when a woman experiences a potentially dangerous rise in blood pressure during pregnancy
- Obesity reduces life expectancy by an average of 3 to 10 years, depending on its severity.
Other obesity-related problems
- Living with obesity can cause various other problems, including difficulties with daily activities, including:.
- Breathlessness
- Increased sweating
- Snoring
- Difficulty doing physical activity
- Extreme tiredness
- Joint and back pain
- Low confidence and self-esteem
- Feeling isolated
- For those with obesity, weight management strategies that include a healthy diet, regular physical activity, and, in some cases, medical or surgical interventions, can help reduce health risks and improve quality of life.
Prevention and Management
- Healthy eating habits
- Regular physical activity
- Behavioral changes
- Medical intervention (in some cases)
- Social support
- Prevention is largely about adopting healthy eating habits, staying active, managing stress, and getting enough sleep. Management involves making consistent, realistic changes to diet and activity levels, and seeking medical support when needed. By combining these approaches, obesity can be prevented and managed effectively, improving both physical and mental well-being.
References
- https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
- https://digital.nhs.uk/data-and-information/publications/statistical/health-survey-for-england/2021/overweight-and-obesity-in-adults
- https://www.gov.uk/government/statistics/update-to-the-obesity-profile-on-fingertips/obesity-profile-short-statistical-commentary-may-2024
Understanding Biolide
What is Biolide?
Biolide is a prescription weight loss medicine that aids weight loss and weight management in adults and adolescents. It contains liraglutide, a glucagon-like peptide-1 (GLP-1) analogue that helps control appetite, making it easier for patients to manage food intake
How does Biolide Work?
Biolide works by activating GLP-1 receptors in the brain, helping increase feelings of fullness while reducing hunger. It is most effective when combined with a healthy diet and regular exercise program, and it may take several weeks to observe noticeable effects.
Who Can Use Biolide?
- Adults with chronic obesity (BMI ≥ 30) or those who are overweight (BMI ≥ 27) with conditions related to weight, such as high blood pressure or type 2 diabetes.
- Adolescents aged 12 years and older diagnosed with obesity and weighing more than 60 kg.
Important Safety Information
Before starting with Biolide, inform your healthcare provider about
- Any allergies, especially to liraglutide or other ingredients in Biolide.
- Existing health conditions like heart failure, kidney or liver problems, or pancreatic diseases.
- This medicine is not recommended if one has a severe stomach or gut problem which results in delayed stomach emptying (called gastroparesis), or if one has an inflammatory bowel disease
- Doctor must be informed if one experiences palpitations or a racing heartbeat while on Biolide
- Pregnancy or breastfeeding plans, as Biolide may not be suitable during these times.
- Any medications you currently take, including diabetes medications and blood thinners.
Administering Biolide
How to Use the Biolide Device
Your healthcare provider will show you the correct way to use the Biolide pre-filled device. Each device contains a colorless solution and can deliver doses ranging from 0.6 mg to 3.0 mg.
Steps for Administration
Examine the Device
Make sure the solution is clear and colorless. Avoid using the device if the solution appears cloudy or has particles.
Select the Injection Area
The abdomen, thighs, or upper arms are the recommended areas for injection. Rotate sites to avoid irritation.
Attach a New Needle
Secure a new needle onto the device before each injection.
Check the Flow
Ensure the dose selector is set to the prescribed dosage.
Administer the Dose
Insert the needle into the skin as directed, press the dose button, and hold for 6 seconds.
Storage Tips
- Store unused device in the refrigerator (2°C–8°C) but avoid freezing.
- Once in use, keep the device at room temperature (below 30°C) for up to one month or refrigerate as needed.
- Always cap the device after each use to protect it from light.
What to Expect with Biolide
Initial Effects and Progress
Common Side Effects
- Nausea or Vomiting
- Diarrhea or Constipation
- Headache and Fatigue
- Injection Site Reactions (mild redness, irritation, or itching)
Serious Side Effects
Although rare, serious side effects like allergic reactions, pancreatitis, or gallbladder issues may occur. Seek medical help if you experience severe abdominal pain, difficulty breathing, or swelling of the face and throat.
Managing Side Effects
- Follow your doctor’s dosage guidance carefully.
- Ensure proper hydration to avoid dehydration.
Frequently Asked Questions
How long will it take to see results?
Weight loss effects vary by individual. Many patients start to notice changes within 12 weeks.
What should I do if I miss a dose?
If you miss a dose, take it as soon as possible on the same day. Do not double up the next dose; continue with your regular schedule.
Can Biolide be used with other medications?
Inform your doctor about all other medications you are taking. Some diabetes medications may require dosage adjustments when used with Biolide.
Patient Support Services
- Access helpful resources, guides, and instructional videos.
- Contact our support team for any additional questions regarding Biolide usage.